1、阐述深层土壤CO2产生对气候变化响应的理论基础。通过理论探讨并结合分析相关实验观测数据，对“深层和表层土壤对气候变化响应一致性”这一学术界新出现的重大论断提出挑战，并在理论上初步提出深层土壤对气候变化响应存在的滞后效应，创造性地利用广义线性模型变换来分析计算不同土壤深度CO2产生的温度敏感性，解决了由于观测数据变异大，进而导致通过传统方法计算温度敏感性大幅偏离理论值的困扰(Science,2018)
2、 发现病原菌MARTX毒素的效应因子RID催化赖氨酸长链脂肪酰基化修饰调节宿主信号通路的全新分子机制（Science，2017）
3、 发现菌根真菌与共生根系功能互补机制。提出菌根真菌调控土壤碳与养分循环耦合的理论框架(Science，2012)
4、 开发了一种新型真菌给药系统，并证实利用这种真菌感染体内有疟原虫的蚊子可显著蚊子体内疟原虫的发育，从而为疟疾的防治提供了一种有潜力的武器。（Science，2011）
5、 利用晶体内聚合酶反应速率减弱的特性，首次在晶体内观测到了完整的DNA聚合酶化学反应过程。（Nature,2012）
6、 发现病原菌利用一类具有全新结构折叠模式的TBC样GAP（GTPase-activating protein），拮抗宿主免疫防御反应的新机制（Cell，2012）
7、 首次提出了细胞营养胁迫与物理接触状态对抗病毒宿主防御的重要调控功能，并深入解析了其由Hippo-YAP通路主导的分子基础。（Nature Cell Biology, 2017）(IF:20.06)
8、 鉴定了抗病毒应答关键激酶TBK1的直接酪氨酸磷酸化修饰以及修饰激酶，提出了酪氨酸磷酸化修饰和酪氨酸激酶在抗病毒天然免疫中的关键调控作用和生理功能，并深入解析了其抑制抗病毒应答和负反馈调控的分子机制。（Cell Host & Microbe, 2017）(IF:14.946)
9、 激活的IRF3利用双重抑制机制控制TGF-β通路中Smad分子的活化和功能性Smad转录复合体的形成。该研究不仅直接证实了宿主防御系统在肿瘤生物学的重要功能，还揭示了TGF-β通路和肿瘤转移新的关键调控因素。（Molecular Cell, 2014）(IF: 14.018)
10、发现气候变化影响土壤有机质分解的微生物学机制。阐明气候变化因子通过促进厌氧土壤中的微生物活性改变养分元素循环(Ecology Letters，2010)（IF:13.327）
11、发现了控制罗伯茨绿僵菌由腐生向寄生转换的一个新遗传通路，鉴定了其中的膜蛋白Mr-OPY2和转录因子AFTF1两个重要成员。（Nature Communications，2017）(IF:13.092)
12、揭示病原菌I-F型CRISPR-Cas系统的抑制机制（Nature Structural & Molecular Biology，2016）（IF:12.17）
13、鉴定了PPM1A是I型干扰素生成的关键生理调控因子，也鉴定了PPM1A为MAVS这一关键抗病毒接头蛋白的首个去磷酸化修饰酶。（Science Advances，2016）
14、揭示病原菌四型b亚型（IVb型）分泌系统接头蛋白复合物调控效应蛋白分泌的分子机理（Proc Natl Acad Sci USA，2017）（IF:10.414）
15、阐明了微孢子虫控制蝗虫行为的机制。微孢子虫通过改变蝗虫的免疫系统和肠道的化学性质，杀死大量的肠道细菌，扰乱了蝗虫的神经系统，诱导和保持群居行为的神经递质的水平下降，最终导致行为异常。（Proc Natl Acad Sci USA，2014）（IF:10.414）
16、揭示了DNA聚合酶η参与完成体细胞超突变的分子机制。（Proc Natl Acad Sci USA，2013）（IF:10.414）
17、研究了墨西哥湾深海溢油事件对深海微生物生态的影响。（ISME J，2012）(IF:11.630)
18、鉴定了Mst1是抗病毒固有免疫应答的重要生理调控蛋白，发现了通过IRF3磷酸化进行活性控制这一新的抗病毒应答的调控模式，指出Mst1为IRF3的首个负调控激酶。（Genes & Development, 2016）(IF:10.042)
19、解析了耐辐射球菌RNase J与RNA复合体的高分辨率晶体构象, 首次为细胞内高浓度锰离子调控RNA代谢相关酶活性提供了直接证据。(Nucleic Acids Res, 2015)(IF: 9.338)
20、解析了耐辐射奇球菌RecJ蛋白（drRecJ）与底物DNA的复合体结构，drRecJ与产物（dTMP）复合体结构，以及drRecJ、DNA与SSB蛋白C末端肽段的三元复合体结构，阐释了RecJ，SSB和RecQ三者参与的RecF途径对DNA损伤末端处理的过程。（eLife,2016）（IF:8.385）
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